Blue light has attracted increasing attention due to its intrinsic antimicrobial effect without the 30 addition of exogenous photosensitizers. However, the use of blue light for wound infections has not been established yet. In this study, we demonstrated the efficacy of blue light at 415 nm for treatment of acute, potentially lethal Pseudomonas aeruginosa burn infections in mice. In vitro studies demonstrated that the inactivation rate of P. aeruginosa cells by blue light was approximately 35-fold faster than that of keratinocytes (P=0.0014). Transmission electron microscopy revealed blue light mediated intracellular damage to P. aeruginosa cells.
Blue Light and Infection